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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mol Genet Metab. 2015 Nov 26;117(1):5–11. doi: 10.1016/j.ymgme.2015.11.012

Figure 5. Effect of Pah genotype and sapropterin treatment upon brain monoamine neurotransmitters.

Figure 5

The concentrations (pmol/mg protein, mean ± SEM) of the monoamine neurotransmitters dopamine (a) and serotonin (b), their metabolites homovanillic acid (HVA) (c) and 5-hydroxyindoleacetic acid (5-HIAA) (d) in half-brain homogenates from wild type (Pah+/+) and Pahenu2/enu2 (Pah−/−) mice following gavage with sapropterin or 1% ascorbic acid are displayed. The data are the means of brain neurotransmitters from all animals obtained at all time points up to six hours after gavage. The horizontal bars represent the statistical significance of the effects of either Genotype or sapropterin Treatment upon the brain monoamine neurotransmitter concentrations as calculated by two way ANOVA.