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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Biomaterials. 2015 Dec 2;80:96–105. doi: 10.1016/j.biomaterials.2015.11.062

Fig. 3. Blocking BSCB breakdown with intravenous APC inhibits nociception after neural injury.

Fig. 3

(A) Spinal IgG is reduced after APC treated 15-minute compression (15min+APC) compared to compression alone (15min). (B) A 15min compression significantly increases (**p=0.028) spinal IgG in the ipsilateral dorsal horn compared to the contralateral dorsal horn on day 1. Ipsilateral IgG for 15min+APC is significantly lower (*p<0.001) than 15min on day 1 and is not different from respective contralateral values. (C) Forepaw withdrawal threshold at day 1 is significantly reduced (*p=0.024) by a 15min compression compared to sham, whereas, 15min+APC exhibits a significantly higher (**p=0.012) withdrawal threshold than 15min, which is not different sham. All data represented as mean±SD.