Table 3.
Univariate and Multivariate Analyses of Parent Outlook Scale and Transplant Difficult and Health Worse Subscale Scores
| Characteristic | Outlook
|
Transplant Difficult
|
Health Worse
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate
|
Multivariate*
|
Univariate
|
Multivariate
|
Univariate
|
Multivariate
|
|||||||
| Beta (SE)† | P | Beta (SE) | P | Beta (SE) | P | Beta (SE) | P | Beta (SE) | P | Beta (SE) | P | |
| Child | ||||||||||||
| Age, yr | 30.7 (0.2) | <.01 | 30.8 (0.3) | <.01 | 30.6 (0.3) | .04 | ||||||
| Female sex | 30.7 (2.3) | .74 | 31.7 (2.7) | .52 | 0.2 (2.7) | .95 | ||||||
| Diagnosis | ||||||||||||
| Solid tumor | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Hematologic malignancy | 37.6 (2.7) | <.001 | 311.0 (4.5) | .01 | 310.1 (3.4) | <.01 | 313.5 (5.7) | .02 | 35.1 (3.5) | .15 | 38.6 (5.4) | .09 |
| Nonmalignancy | 36.5 (3.2) | .04 | 312.5 (4.9) | .01 | 35.8 (3.9) | .14 | 311.2 (6.3) | .08 | 37.2 (4.0) | .07 | 313.7 (5.9) | .02 |
| Months (log) since diagnosis | 1.2 (1.0) | .23 | 1.3 (1.2) | .27 | 1.0 (1.2) | .38 | ||||||
| Previous treatment unsuccessful | 3.3 (2.5) | .18 | 0.49 (2.8) | .86 | 6.0 (2.9) | .04 | ||||||
| HSCT type | ||||||||||||
| Autologous | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Allogeneic related | 37.0 (3.3) | .03 | 4.6 (4.2) | .32 | 36.9 (4.0) | .08 | 5.0 (5.4) | .38 | 36.9 (3.9) | .07 | 4.4 (5.1) | .39 |
| Allogeneic unrelated | 0.1 (2.6) | .96 | 10.8 (4.0) | .01 | 30.7 (3.2) | .83 | 10.6 (5.1) | .04 | 1.0 (3.1) | .75 | 10.9 (4.8) | .02 |
| General health (parent report) | 30.2 (.04) | <.001 | 30.1 (.04) | .03 | 30.2 (.05) | <.001 | 30.1 (.05) | .15 | 30.2 (.04) | <.001 | 30.1 (.04) | .04 |
| Parent | ||||||||||||
| Age, yr | 30.4 (0.2) | .02 | 30.5 (0.2) | .02 | 30.3 (0.19) | .1 | ||||||
| Female sex | 1.4 (2.7) | .61 | 0.3 (3.3) | .92 | 2.4 (3.3) | .45 | ||||||
| White non-Hispanic | 7.9 (2.5) | <.01 | 4.9 (3.1) | .11 | 10.8 (3.0) | <.001 | ||||||
| Postsecondary education | 30.7 (2.5) | .77 | 34.9 (2.9) | .1 | 3.2 (3.0) | .29 | ||||||
| Married/living with partner | 2.2 (3.2) | .49 | 0.6 (3.8) | .87 | 3.6 (3.7) | .33 | ||||||
| Emotional functioning | 30.6 (.06) | <.001 | 30.5 (.05) | <.001 | 30.5 (.07) | <.001 | 30.5 (.07) | <.001 | 30.6 (.06) | <.001 | 30.5 (.06) | <.001 |
HSCT indicates hematopoietic stem cell transplantation; SE, standard error; Ref, reference value. Significant P values are in bold type.
*
Multivariable models were adjusted for transplantation center, study/study arm, and timing of baseline assessment relative to the start of the preparative regimen.
†
Higher score (positive estimate) reflects greater frequency of parent thoughts about the potential difficulty of the transplantation course or their child’s worsened future health. The SEs presented are robust SEs.