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The time course followed for applying the AAV-CMV vector. Early brain lesions estimated by rADC below the threshold values (see Fig 1c). The tthreshold of ADC in normal mice (n = 6 at different dates and different litters of mice) was established using power analysis after BCAO at normal temperature (Each data point after BAO was obtained from at least n ≥ 4, Data adapted from our previous publication)32.
