Table I.

Tumorigenicity of azoxymethane (AOM) in WT and athymic BALB/c mice.

strain	# of mice	treatmenta	adenomasd (%)	total adenomase	adenocarcinomaf (%)
WT BALB/c	23	solventb	1 (<1)	1	0
athymic BALB/c	22	solventb	1 (<1)	1	0
WT BALB/c	70	AOMc	44 (63)g	79	15 (21)h
athymic BALB/c	69	AOMc	4 (6)g	4	3 (4)h

^aanimals received 6 weekly i.p. doses of solvent or AOM.

^b200 µL 2% phosphate buffered saline (PBS).

^c10 mg/kg of AOM dissolved in 200 µL of PBS.

^dadenoma bearing mice by macroscopic inspection.

^etotal number of macroscopic adenomas.

^fdetermined by histopathological examination.

^gstatistically different from each other (p < 0.0001) using Person’s chi-square test.

^hstatistically different from each other (p < 0.003) using T-test.