. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Mol Carcinog. 2015 Jul 8;55(7):1187–1195. doi: 10.1002/mc.22361

Table III.

Tumorigenicity of azoxymethane (AOM) followed by dextran sulfate sodium (DSS) in WT and immune compromised C67Bl/6 mice

Treatment	Mouse Strain	# of mice	Incidence	Adenomas	Carcinomas	Multiplicity
10 mg/kg AOM + 2% DSS	Foxn1/J^a	20	14	6	16	22
10 mg/kg AOM + 2% DSS	Foxn1^nu/J^b	20	n/a^c	n/a	n/a	n/a
10 mg/kg AOM + 1% DSS	Foxn1/J^a	20	0	-	-	-
10 mg/kg AOM + 1% DSS	Foxn1^nu/J^b	20	0	-	-	-
15 mg/kg AOM + 1.5% DSS	Foxn1/J^a	14	12	11^d	22^e,^j	32
15 mg/kg AOM + 1.5% DSS	Foxn1^nu/J^b	12	11	19^d	7^e	26
15 mg/kg AOM + 1.5% DSS	WT	12	7^f,^g	7	6^j	13^h,ⁱ
	TCRβ^−/−	10	1^f,^k	1^l	0	1^h,^m
	TCRδ^−/−	9	3	3	0	3
	TCRβ^−/−δ^−/−	9	1^g	1	0	1ⁱ
10 mg/kg AOM + 2% DSS	WT	12	10	11	10	21
10 mg/kg AOM + 2% DSS	TCRβ^−/−	12	11^k	10^l	12	22^m

heterozygote B6.

homozygote (athymic) B6.

animals died or had to be sacrificed immediately after exposure to DSS.

p-value: 0.020 (T-test).

p-value: 0.046 (T-test).

p-value: 0.026 (Fisher’s exact test).

p-value: 0.038 (Fisher’s exact test).

p-value: 0.024 (T-test).

ⁱ

p-value: 0.025 (T-test).

p-value: 0.027 (T-test).

p-value: 0.015 (Fisher’s exact test).

p-value: 0.012 (T-test).

p-value 9.250e⁻⁰⁵(T-test).