Fig. 3.

Effects of LY379268 on cue-induced reinstatement of extinguished drug-seeking behavior in nicotine- or cocaine-experienced monkeys. LY379268 (0.01, 0.03, 0.1, 0.3, or 1 mg/kg) or vehicle was administered prior to the sessions, in which cue presentations and saline injections were not present or were reinstated. Lever presses produced per 1-h sessions are shown in nicotine- (a) or cocaine-experienced (b) monkeys. Bars represent means±SEM from four (a) or three (b) monkeys.”No cues + 0 mg/kg” bars represent the average of five extinction sessions prior to the test sessions. “Cues + 0 mg/kg” bars represent the average of two tests. *p<0.05, post hoc comparisons with “no cues + 0 mg/kg” condition; #p<0.05, post hoc comparisons with “cues + 0 mg/kg,” Tukey test