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Combination of a cytotoxic platinum agent with a less cytotoxic drug sensitizer ethacrynic acid to minimize the glutathione mediated Pt detoxification. (A) Chemical structure of P(Pt) and P(EA). (B) Schematic illustration of self-assembling P(Pt) and P(EA) into M(EA/Pt) and its intracellular fate. (C) In-vivo evaluation of tumor inhibition effect of M(EA/Pt). (D) In-vivo evaluation of body weight change after treatment of M(EA/Pt).
