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. 2015 Dec;12(4):362–374. doi: 10.7497/j.issn.2095-3941.2015.0063

Table 3. General combination therapy strategy for two anticancer drugs.

Categories Combination strategy Advantages/drawbacks
Conjugate A+ free B Inline graphic Starting drug ratio tunable; difference in metabolism
Conjugate A+ conjugate B Inline graphic Starting drug ratio tunable; difference in metabolism
A and B co-conjugate Inline graphic Starting drug ratio tunable; similar metabolism
A-NPs+ free B Inline graphic Starting drug ratio tunable; difference in metabolism; minimum change drug ratio at circulation
A-NPs+ B-NPs Inline graphic Drug ratio tunable; difference in metabolism;
A and B co-loaded NPs Inline graphic Starting drug ratio tunable; difference in metabolism; minimum change drug ratio at circulation