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. 2015 Dec;12(4):401–408. doi: 10.7497/j.issn.2095-3941.2015.0013

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2015 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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CAL-101 and bortezomib synergistically interact in Z138, HBL-2, and Jeko-1 cells. (A) CAL-101/bortezomib combination significantly suppressed viability of MCL cells compared with single-agent CAL-101 or BTZ through MTT. (B) CAL-101/bortezomib combination induced significantly synergistic cytotoxicity in MCL cells by CalcuSyn software calculation [Combination index (CI) <1.0]. CI values <1.0 indicates a synergistic interaction and CI values >1.0 indicates antagonistic drug effects. A straight line at CI =1.0 represents additive effects of both drugs. (C) Inhibitory effect of CAL-101 on the viability of Z138, HBL-2, and Jeko-1 cells was time dependent.