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. 2015 Dec;12(4):328–341. doi: 10.7497/j.issn.2095-3941.2015.0024

Table 2. Summary of the roles of miRNAs associated with diagnosis and prognosis, type of tissue taken, number of sample taken, and discovery platform used.

MiRNAs Up/down-regulated Diagnosis/prognosis Type of tissue No. of samples Discovery platform References
MiR-21 Up-regulated Diagnosis and prognosis both Blood/serum 94 patients with primary EOC Real-time RT-PCR assay 78
MiR-141, miR-200a/b/c Up-regulated Diagnosis Tissue sample 84 snap-frozen normal and malignant ovarian tissues MiRNA microarray hybridization 30,40
MiR-199, miR-140, miR-145, miR125b Down-regulated Diagnosis Tissue sample 84 normal and malignant ovarian tissues MiRNA microarray hybridization 30
MiR-484, miR-642, and MiR-217 Down-regulated Prognosis Tumor tissue 112 EOC samples Quantitative RT-PCR 79
MiR-221 Up-regulated Diagnosis and prognosis Serum 96 patients with EOC Real-time RT-PCR assay 68
MiR-31 Down-regulated Chemoresistance KFr13Tx cell lines - Real-time PCR 67
MiRs-21, 92, 93, 126 and 29a Up-regulated Diagnosis and prognosis Serum 28 patients with EOC TaqMan real-time PCR 74
MiRs-155, 127 and 99b Down-regulated Diagnosis and prognosis Serum TaqMan real-time PCR 74
MiR-182 Up-regulated Prognosis (chemoresistance) Tumor tissue as well as cell lines 15 ovarian tissue samples and 2 cell lines Real-time PCR 80
MiR-23a, miR-27a, miR-21 and miR24-2 Up-regulated Prognosis Tumor tissue sample 56 ovarian cancer samples Microarrays. 75
MiR-21, 141, 200a, 200b, 200c, 203, 205, and 214 Up-regulated Diagnosis Serum 50 ovarian cancer patients MiRNA-microarrays 73
MiR-30c, 30d, 30e-3p, and 370 Up-regulated Clinicopathologic variables Ovarian cancer tissue block 171 Formalin fixed paraffin embedded tissue Taqman based RT-PCR 72
MiR-221 Up-regulated Prognosis Serum 96 EOC samples Real-time PCR 81
Let-7i Down-regulated Prognosis (chemotherapy response) Tissue sample 72 patients and 4 ovarian cancer cell lines MiRNA-microarrays 34
MiR-9 Down-regulated Diagnostic for recurrent ovarian cancer Tissue sample 18 fresh frozen and 22FFPE EOC samples Real-time PCR 82
MiR-223 Up-regulated Diagnostic for recurrent ovarian cancer Tissue sample 18 fresh frozen and 22FFPE EOC samples Real-time PCR 82

EOC, epithelial ovarian cancer.