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Bactericidal activity in serum samples of mice immunized three times with decreasing amounts of N19-MenC or CRM-MenC (2.5, 0.625, 0.156, and 0.039 μg of MenC/dose) and 0.5 mg of aluminium hydroxide. Bactericidal antibody titers from pooled serum samples collected before (pre) and after (post-1, -2, and -3) each immunization are shown. Results are expressed as reciprocal values of the highest serum dilution giving at least 50% bacterial killing.
