TABLE 1.
Universal human CD4+ T-cell epitopes contained in the N19 recombinant polyepitopea
| Pathogen | Antigen | Epitope | Amino acid position | Amino acid sequence |
|---|---|---|---|---|
| Clostridium tetani | Tetanus toxin | P23TT | 1084-1099 | VSIDKFRIFCKANPK |
| C. tetani | Tetanus toxin | P32TT | 1174-1189 | LKFIIKRYTPNNEIDS |
| C. tetani | Tetanus toxin | P21TT | 1064-1079 | IREDNNITLKLDRCNN |
| Plasmodium falciparum | Circumsporozoite protein | PfT3 | 380-398 | EKKIAAKMEKASSVFNVVN |
| C. tetani | Tetanus toxin | P30TT | 947-967 | FNNFTVSFWLRVPKVVSASHLE |
| C. tetani | Tetanus toxin | P2TT | 830-843 | QYIKANSKFIGITE |
| HBV | Nucleocapsid | 50-69 | PHHTALRQAILCWGELMTLA | |
| Influenza virus | Hemagglutinin | 307-319 | PKYVKQNTLKLAT | |
| HBV | Surface antigen | 19-33 | FFLLTRILTIPQSLD | |
| Influenza virus | Matrix protein | 17-31 | YSGPLKAEIAQRLEDV |
a
See reference 10 for references specific to each T-cell epitope present in the N19 protein. HBV, hepatitis B virus.