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. 2016 Jan 8;9:3. doi: 10.1186/s13041-015-0181-3

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© Yang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Clomipramine (CLI) relieved social avoidance and anxiety-like behavior. a Schematic representation of the SD and CLI administration protocol; b & c I.p. injection of CLI (10 mg/kg) increased the SIR (b) and decreased proportion of susceptible individuals (c) compared to the normal saline (NS) in the social interaction test (SIT); d & e CLI reversed SD stress-induced decreases in central-zone distance (d) and time (e) in open field test (OFT); f & g CLI reversed SD stress-induced decreases in both open-arm entries and time in elevated plus maze (EPM) test. *p < 0.05, **p < 0.01 verse NS control.