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. 2016 Jan 8;9:3. doi: 10.1186/s13041-015-0181-3

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© Yang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Inhibition of PKA in the BLA aggravated moderate social defeat-induced anxiety but not social avoidance. a Schematic representation of a protocol for 10-day H-89/8-Br-cAMP administration during a moderate SD stress (the exposure time to aggressors was shortened from 10 min to 5 min each day); b photomicrograph of coronal section and histological reconstruction of microinjection sites by osmotic pump system in the bilateral BLA; c Continuous PKA activator 8-Br-cAMP (8-Br, 2 μg/d) and inhibitor H-89 (0.3 μg/d) over the 10-day defeat did not affect the social interaction behaviors; d & e 8-Br-cAMP alleviated moderate SD-induced anxiety in the OFT (d) and EPM test (e), whereas H-89 significantly aggravated moderate SD-induced anxiety in the EPM test. *p < 0.05, **p < 0.01 verse NS control.