Table 1.
Case 1 | Case 2 | Case 3 | |
---|---|---|---|
Primary organ pathology | Alcoholic liver disease | Tubulo-interstitial nephritis with focal sclerosis | End stage renal failure of unknown aetiology (diabetes/hypertension) |
Age at transplantation (years) | 58 | 48 | 57 |
Ethnicity | Caucasian | Black Caribbean | Indian |
Organ transplanted | Liver | Kidney | Kidney |
Class 1 HLA type | A01, A24, B08, B15, C03, C07 DR1, DR3 DQ2, DQ5 |
A3, A34, B51, B71, Cw3, Cw16, DR13, DQ7 |
A3, A24; B52, B55; Cw1, Cw12; DR10 DR14; DQ5 |
Peri-operative immune suppression | Basiliximab Methylprednisolone |
Basiliximab Methylprednisolone |
Basiliximab Mycophenolate, Tacrolimus |
Post operative immune suppression | Mycophenolate, tacrolimus | None | Tacrolimus, prednisolone |
Day post transplant antiretrovirals commenced | Day 19 | Day 17 | Day 26 |
Dose of antiretrovirals | Zidovudine 250 mg bd Raltegravir 400 mg bd |
Zidovudine 100 mg tds Raltegravir 400 mg bd |
Zidovudine 100 mg tds Raltegravir 400 mg bd |
Day antiretrovirals stopped | Day 66 | Day 43 | Day 80 |
Day organ removed | Not applicable | Day 0 | Day 48 |
Indication for organ removal | Not applicable | Life-threatening intra-operative haemorrhage | Rejection/failure |
b.d. Bis in die (twice a day), t.d.s. ter die sumendum (three times daily)