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. 2015 Dec 30;183(2):96–109. doi: 10.1093/aje/kwv187

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© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 1. — Epigenetic features that mark active and repressed genes. Active enhancers, promoters, and gene bodies are marked by H3K4me1+H3K27ac, H3K4me3+H3K9ac, and H3K79me2+ H3K36me3, respectively; 5-methylcytosine (5meC) is often detected in the gene bodies. Inactive enhancers, promoters, and gene bodies are marked by H3K9me2/3 and H3K27me3; 5meC also occurs in the promoters. H3K4me1, histone H3 lysine 4 monomethylation; H3K4me3, histone H3 lysine 4 trimethylation; H3K9ac, histone H3 lysine 9 acetylation; H3K9me2, histone H3 lysine 9 dimethylation; H3K9me3, histone H3 lysine 9 trimethylation; H3K27ac, histone H3 lysine 27 acetylation; H3K27me3, histone H3 lysine 27 trimethylation; H3K36me3, histone H3 lysine 36 trimethylation; H3K79me2, histone H3 lysine 79 dimethylation.