Table 3.

Clinical and pathological ovarian cancer characteristics determined by the BRCA1 gene status

Status BRCA1	Wild type (n = 108)	Germline mutation (n = 17)	Statistics	p value
Median (range) age at diagnosis in years	56 (28–85)	47 (39–70)	−2.859a	0.004
Performance status WHO:
▪ 0	15	4
▪ Other	93	13	0.44b	0.51
FIGO stage:
▪ Early (I, II)	22	3
▪ Advanced (III,IV)	86	14	0.07b	0.95
Chemotherapy regimen:
▪ With paclitaxel	97	16
▪ Without paclitaxel	11	1	0.01b	0.91
Chemotherapy regimen:
▪ With cisplatin	47	8
▪ With carboplatin	61	9	0.1c	0.75
Type of histology:
▪ Serous	57	11
▪ Other	51	6	0.84c	0.36
Grading:
▪ 1 and 2	38	7
▪ 3 and unspecified	70	10	0.23c	0.63
Primary surgery:
▪ Optimal (<1 cm)	68	9
▪ Suboptimal (>1 cm)	40	8	0.62c	0.43

^aMann–Whitney U test

^bYates-corrected Chi-square test

^cChi-square test