TABLE 2.
CDR1 and CDR2 sequences of XenoMouse mouse human, human, and murine-derived MAbs to GXM
| MAb-VH | Origin, immunogen | Sequencea
|
Efficacy | Reference | |
|---|---|---|---|---|---|
| CDR1 (positions 31 to 35) | CDR2 | ||||
| 2E9-VH3 | Human, GXM-TT | NYWMT | NIKQDGGERYYVGSVTG | Protective | 49 |
| 3B6-VH3 | Human, GXM-TT | NYAMG | GISGSGGTSHFADSVKG | Unknown | 49 |
| G15-VH3 | XenoMouse mouse, GXM-DT | SYAMH | AISSNGGsTYYADSVKG | Protective | This report |
| 12A1-7183 | Mouse, GXM-TT | NYFMS | MININGNNTYYPDTVKG | Protective | 40, 43 |
| 13F1-7183 | Mouse, GXM-TT | SYyMS | AINSNGGsTYYPDTVKG | Nonprotective | 40, 43 |
| G14-VH6 | XenoMouse mouse, GXM-DT | SNNAAWN | RTYFRSKWYNDYAVSVKS | Nonprotective | This report |
| G19-VH6 | XenoMouse mouse, GXM-DT | SNNAAWN | RTYYRSYWYNDYAVSVKS | Nonprotective | This report |
| Human VH3/mouse, GXM binding | N/SY--- | -I---G----YYb---V-G | |||
a
Boldface underlining, residues shared between mouse and XenoMouse mouse MAbs; boldface italics, residues generated by somatic mutation (36) (this report); italics, residues similar between MAbs but in different position; lowercase, residues associated with diminished GXM binding (36).
b
Not in 3B6 because of somatic mutations.