Table 2.
Functional observational battery (FOB) findings.
| FOB areas and measures | Exposure group
|
||||||
|---|---|---|---|---|---|---|---|
| BGVC | G/MTBE | G/EtOH | G/TAME | G/ETBE | G/DIPE | G/TBA | |
| Home cage evaluations | |||||||
| Posture vocalization | X | X | X | X | X | X | X |
| Palpebral closure | X | X | X | X | |||
| Handling evaluations | |||||||
| Ease of removal | X | X | X | X | X | ||
| Ease of handling | X | X | |||||
| Chromodacryorrhea | X | X | X | X | |||
| Lacrimation | X | X | |||||
| Salivation | |||||||
| Altered fur appearance | |||||||
| Open field evaluations | |||||||
| Gait and posture | |||||||
| Locomotion | X | X | X | ||||
| Arousal level | X | X | X | ||||
| Exophthalmia | |||||||
| Piloerection | X | X | |||||
| Defecation count | X | X | X | X | X | X | X |
| Urination count | X | X | X | X | X | X | X |
| Fasciculation | |||||||
| Tremors | |||||||
| Convulsions | |||||||
| Reflex assessments | |||||||
| Response to visual stimuli | X | X | X | X | X | ||
| Response to auditory stimuli | |||||||
| Pain perception | X | X | |||||
| Pupillary response | X | X | |||||
| Sensitivity to light touch | X | X | X | X | X | X | |
| Proprioception | |||||||
| Other | |||||||
| Forelimb grip strength* | O | ||||||
| Hindlimb grip strength* | O,B | ||||||
| Air righting ability | |||||||
| Landing foot splay* | B | ||||||
| Body weight* | O, B | O, B | O, B | O, B | O | O, B | |
X – demonstrated non-statistically significant variation.
O = observed data not normally distributed; B = Blom transformed data not normally distributed.
A blank box indicates there was not a statistically significant exposure-related difference in the endpoint evaluated.
*
Analyzed as a continuous variable.