Table 3.
Mean GFAP levels on specific regions of rat brains following a 13 week whole body inhalation exposure to baseline gasoline (BGVC) vapor condensate.
| Brain area | Control | 2000 mg/m3 | 10,000 mg/m3 | 20,0000 mg/m3 |
|---|---|---|---|---|
| Males (N = 5) | ||||
| Striatum | 1.01 ± 0.09a | 0.89 ± 0.18 | 0.84 ± 0.17 | 0.93 ± 0.09 |
| Hippocampus | 2.88 ± 0.24 | 3.08 ± 0.27 | 2.63 ± 0.21 | 2.76 ± 0.12 |
| Cortex | 1.31 ± 0.14 | 1.44 ± 0.07 | 1.43 ± 0.13 | 1.20 ± 0.06 |
| Olfactory bulb | 2.49 ± 0.21 | 2.73 ± 0.47 | 2.26 ± 0.23 | 2.36 ± 0.12 |
| Thalamus | 2.15 ± 0.23 | 2.17 ± 0.29 | 1.71 ± 0.19 | 1.88 ± 0.10 |
| Hypothalamus | 8.62 ± 0.81 | 7.46 ± 0.84 | 6.82 ± 0.74 | 6.66 ± 0.90 |
| Cerebellum | 4.63 ± 0.37 | 4.09 ± 0.49 | 3.72 ± 0.28 | 3.93 ± 0.25 |
| Rest of brain | 4.70 ± 0.34 | 5.48 ± 0.58 | 3.81 ± 0.39 | 5.11 ± 0.38 |
| Females (N = 5) | ||||
| Striatum | 0.90 ± 0.13 | 0.82 ± 0.05 | 0.95 ± 0.04 | 0.87 ± 0.11 |
| Hippocampus | 2.83 ± 0.18 | 2.46 ± 0.06 | 3.06 ± 0.20 | 2.89 ± 0.36 |
| Cortex | 1.57 ± 0.14 | 1.50 ± 0.12 | 1.84 ± 0.28 | 1.60 ± 0.22 |
| Olfactory bulb | 2.34 ± 0.26 | 2.49 ± 0.28 | 2.70 ± 0.27 | 2.50 ± 0.26 |
| Thalamus | 2.12 ± 0.23 | 1.64 ± 0.12 | 2.02 ± 0.23 | 1.88 ± 0.23 |
| Hypothalamus | 8.71 ± 0.90 | 6.13 ± 0.36 | 8.36 ± 1.30 | 7.71 ± 0.90 |
| Cerebellum | 3.98 ± 0.36 | 3.04 ± 0.35 | 4.29 ± 0.54 | 4.23 ± 0.40 |
| Rest of brain | 4.59 ± 0.37 | 4.87 ± 0.23 | 4.93 ± 0.30 | 4.91 ± 0.37 |
a
Each value represents the mean ± SEM for the concentration of GFAP (μg/mg total protein).