Table 4.
Mean GFAP levels on specific regions of rat brains following a 13 week whole body inhalation exposure to gasoline MTBE (G/MTBE) vapor condensate.
| Brain areaA1:E20 | Control | 2000 mg/m3 | 10,000 mg/m3 | 20,0000 mg/m3 |
|---|---|---|---|---|
| Males (N = 5) | ||||
| Striatum | 0.94 ± 0.14a | 0.97 ± 0.13 | 1.08 ± 0.16 | 0.83 ± 0.07 |
| Hippocampus | 2.62 ± 0.23 | 3.45 ± 0.30b | 3.18 ± 0.28 | 3.02 ± 0.12 |
| Cortex | 1.37 ± 0.06 | 1.66 ± 0.20 | 1.65 ± 0.10 | 1.28 ± 0.11 |
| Olfactory bulb | 2.14 ± 0.14 | 2.45 ± 0.23 | 2.06 ± 0.17 | 2.36 ± 0.15 |
| Thalamus | 1.90 ± 0.08 | 2.19 ± 0.20 | 2.04 ± 0.08 | 2.13 ± 0.08 |
| Hypothalamus | 6.04 ± 0.99 | 6.64 ± 0.93 | 6.63 ± 0.79 | 6.09 ± 0.71 |
| Cerebellum | 5.97 ± 0.17 | 6.53 ± 0.38 | 5.99 ± 0.56 | 6.23 ± 0.43 |
| Rest of brain | 4.19 ± 0.42 | 5.81 ± 0.51b | 5.58 ± 0.27b | 5.08 ± 0.49 |
| Females (N = 5) | ||||
| Striatum | 0.93 ± 0.06 | 0.96 ± 0.09 | 0.83 ± 0.06 | 0.78 ± 0.05 |
| Hippocampus | 2.67 ± 0.08 | 3.12 ± 0.20 | 2.64 ± 0.16 | 2.60 ± 0.14 |
| Cortex | 1.23 ± 0.05 | 1.26 ± 0.10 | 1.18 ± 0.10 | 1.04 ± 0.07 |
| Olfactory bulb | 1.91 ± 0.16 | 1.92 ± 0.16 | 2.01 ± 0.09 | 2.01 ± 0.15 |
| Thalamus | 1.58 ± 0.13 | 1.96 ± 0.25b | 1.64 ± 0.08 | 1.43 ± 0.06 |
| Hypothalamus | 5.67 ± 0.65 | 6.59 ± 0.61 | 4.86 ± 0.11 | 5.08 ± 0.52 |
| Cerebellum | 5.22 ± 0.49 | 5.18 ± 0.78 | 4.94 ± 0.26 | 4.16 ± 0.36 |
| Rest of brain | 4.62 ± 0.51 | 4.54 ± 0.30 | 4.04 ± 0.22 | 4.29 ± 0.26 |
a
Each value represents the mean ± SEM for the concentration of GFAP (μg/mg total protein).
b
Statistically different from control (p < 0.05).