Table 2.
Experimentally determined and predicted SRcocrystal values from measured SRdrug values in FeSSIF and buffer with initial pH of 5.00.
| Cocrystal | SRdrug, expa |
pHb FeSSIF |
pHb buffer |
SRcocrystal, predc |
SRcocrystalcexpd | pHb FeSSIF |
pHb buffer |
|---|---|---|---|---|---|---|---|
| CBZ-SAC (1:1) |
1.8 ± 0.1 | 4.86±0.05 | 4.95±0.01 | 1.3 | 1.03±0.04 | 3.11±0.02 | 3.08±0.03 |
| CBZ-SLC (1:1) |
1.8 ± 0.1 | 4.86±0.05 | 4.95±0.01 | 1.3 | 1.33±0.05 | 4.29±0.02 | 4.37±0.02 |
| CBZ-4ABA (H) (2:1) |
1.8 ± 0.1 | 4.86±0.05 | 4.95±0.01 | 1.5 | 1.49±0.06 | 4.94±0.02 | 4.84±0.03 |
| PXC-SAC (1:1) |
2.0 ± 0.2 | 5.02±0.02 | 4.98±0.01 | 1.4 | 1.40±0.03 | 3.79±0.02 | 3.64±0.02 |
| IND-SAC (1:1) |
16 ± 1 | 4.98±0.06 | 4.96±0.03 | 4.0 | 4.5±0.3 | 3.65±0.05 | 3.66±0.02 |
| DNZ-HBA (1:1) |
766 ± 80 | 5.01±0.05 | 4.96±0.01 | 27 | 23±3 | 4.46±0.06 | 4.47±0.04 |
| DNZ-VAN (1:1) |
766 ± 80 | 5.01±0.05 | 4.96±0.01 | 27 | 24±4 | 5.00±0.01 | 4.96±0.01 |
a)
Experimentally measured in absence of coformer.
b)
pH at equilibrium.
c)
Predicted from experimental SRdrug values using equation (1) for 1:1 cocrystals and (2) for 2:1 cocrystals.
d)
Determined from Scocrystal measurement at eutectic points, extrapolated to stoichiometric conditions according to equations (8) and (9) in the methods section.