Table 5.
Sensitivity Analysis of Pre-Operative Determinants of Pain Cessation Rate Multivariate Modelsa
| Multivariate Model Variation | Anxiety Sensitivity Index Scorea | Self-Perceived Risk of Addictiona | Fear of Pain Scorea | Preoperative Illicit Opioid Use |
|---|---|---|---|---|
| HR (95%CI); P-Value | HR (95%CI); P-Value | HR (95%CI); P-Value | HR (95%CI); P-Value | |
| Full model | 1.89(1.23–2.90);0.004 | 0.62(0.39–0.97);0.04 | 0.65(0.40–1.06);0.08 | 0.53(0.24–1.16);0.11 |
| Models Using Specific Patient Subsets | ||||
| Thoracotomy Patients Omitted | 1.87(.120–2.92);0.006 | 0.67(0.43–1.10);0.12 | 0.57(0.33–0.97);0.04 | 0.64(0.29–1.43);0.28 |
| Total Knee Replacement Patients Omitted | 1.54(0.96–2.47);0.08 | 0.66(0.41–1.05);0.08 | 0.65(0.37–1.14);0.13 | 0.51(0.21–1.28);0.15 |
| Total Hip Replacement Patients Omitted | 1.85(1.07–3.18);0.03 | 0.58(0.34–0.98);0.04 | 0.64(0.37–1.13);0.12 | 0.55(0.21–1.41);0.21 |
| Mastectomy Patients Omitted | 1.64(1.03–2.61);0.04 | 0.49(0.24–1.01);0.05 | 0.91(0.52–1.57);0.72 | 0.48(0.18–1.28);0.14 |
| Lumpectomy Patients Omitted | 2.00(1.28–3.12);0.002 | 0.65(0.41–1.02);0.06 | 0.61(0.37–1.01);0.05 | 0.49(0.22–1.08);0.08 |
| Opioid Naïve Patients only | 1.73(0.98–3.04);0.06 | 0.54(0.310.94);0.03 | 0.59(0.31–0.94);0.08 | N/A |
a
Hazard ratios presented as the difference in hazard between 25th percentile and 75th percentile of that variable in the study population.
All models are stratified by surgery type.