HCAECs were maintained in EBM-2 alone (Control) or EBM-2 containing tunicamycin (“Tun”, 10 μg/ml, 30 min) or thapsigargin (“Thaps”, 1 μM, 10 min) and in the presence or absence of the TRPC3 selective blocker Pyr10 (2 μM), as indicated. Following treatments, cells were processed for immunodetection of phospho-CAMKII (Thr286; ~50 kDa) in whole cell lysates. Membranes were reprobed for GAPDH (~37 kDa) to control for protein loading.