Skip to main content
. 2004 Aug;72(8):4827–4835. doi: 10.1128/IAI.72.8.4827-4835.2004

FIG. 2.

FIG. 2.

Binding of purified Dr fimbriae to glomerulus and renal BM of human kidney. Cryostat sections of human kidney were incubated with Dr fimbriae purified from E. coli Dr(pCC90) (DAF+ COL+) or E. coli Dr(pCC90-I113T) (DAF+ COL−) to detect tissue tropism to glomerular and renal interstitial structures. (A) Hematoxylin and eosin staining of kidney. (B) Distribution of type IV collagen in human kidney. (C) Dr fimbriae showed intense binding to Bowman's capsule and BMs of the renal tubules. (D) DrI113T fimbriae from collagen-binding mutant completely lost binding to Bowman's capsule and BMs of the renal tubules. All micrographs were taken at magnification ×1,000. The glomeruli are indicated by arrows, and the tubules are indicated by arrowheads.