Table 1.
Characteristics, chemistry values, and clinical symptoms in 48 patients with STEC-HUS mediated by Escherichia coli O104:H4.
| Variable | Admission | Day 3 |
|---|---|---|
| Demographics | ||
| Number of patients (n, %) | 48 (100) | |
| Age (years, median (IQR)) | 45 (27–57) | |
| Female sex (n, %) | 35 (72.9) | |
| Positive test for Shiga toxin or EHEC (n, %) | 45 (93.8) | |
| Onset of diarrhea (median (IQR)) | 2 (1–4) | |
| Medical history (n, %) | ||
| Arterial hypertension | 11 (22.9) | |
| Diabetes mellitus | 2 (4.2) | |
| Coronary heart disease | 2 (4.2) | |
| Chronic kidney disease | 0 (0) | |
| Laboratory data (median (IQR)) | ||
| Creatinine (μmol/L) | 202 (120–335) | 264.5 (184.8–344) |
| eGFR (mL/min/1.73 m2) | 26 (15–51.5) | 20 (13–33) |
| LDH (U/L) | 1018 (749–1429) | 886 (651–1142.3) |
| Platelets (/nL) | 46 (32–64) | 52 (23–72) |
| Hemoglobin (g/dL) | 11.2 (9.8–12.4) | 9.2 (8.3–10.4) |
| Angiopoietin-1 [ng/mL] | 1.5 (0.7–2.1) | 1.36 (0.95–2.29) |
| Angiopoietin-2 [ng/mL] | 2.4 (2–3.2) | 2.6 (1.8–3.28) |
| Clinical data (n, %) | ||
| Complicated course | 32 (66.7) | |
| Need of RRT | 32 (66.7) | |
| Seizures | 10 (20.8) | |
| Need of mechanical ventilation | 9 (18.8) | |