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. 2015 Sep 7;4(1):28–38. doi: 10.1002/mgg3.176

Figure 4.

Figure 4

Variable positions for indel 15. The alignment covers the DPP sequence between ID14 and ID16. ID15 is an 18‐bp deletion relative to the reference sequence. Here, ID15 is placed in a different position each DPP length haplotype that contains it. ID15 could be placed at any position between ID14 and ID16. When aligning such sequences, Occam's razor is applied to minimize the number of genetic events required to explain the variation. As a result the dashes are aligned at a somewhat arbitrary location (as in Fig. S2), which suggests that the indel was generated at a single time and position and is present in multiple sequences through common descent. The tree, however, suggests that ID15 was generated independently in three lines. The C in bold is the site of a single bp deletion that caused DD‐II (c.3135delC). DPP, dentin phosphoprotein; DD‐II, dentin dysplasia type II.