Table 1.
MC4R allelic frequencies according to this study population and from the 1000 Genomes Project
| MC4R variant | This study (%) | 1000 Genomes (%)a | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Black African (n = 187) | White Caucasian (n = 66) | Mixed ancestry (n = 21) | Indian (n = 23) | Global | Total African (n = 661) | African continentb (n = 504) | European (n = 503) | American (n = 347) | East Asian (n = 504) | South Asian (n = 489) | |
| R7H (rs142837166) | 0.27 | 0 | 0 | 0 | – | – | – | – | – | – | – |
| S36T | 0.27 | 0 | 0 | 0 | – | – | – | – | – | – | – |
| V103I (rs2229616) | 5.08 | 0.80 | 0.54 | 0 | 1.62 | 1.97 | 1.98 | 0.70 | 0.87 | 1.79 | 2.45 |
| R165Q | 0.27 | 0 | 0 | 0 | – | – | – | – | – | – | – |
| I170V (rs121913560) | 2.14 | 0 | 0.27 | 0 | 0.08 | 0.30 | 0.40 | 0 | 0 | 0 | 0 |
| I198I (rs61741819) | 1.34 | 0 | 0.54 | 0 | 1.28 | 4.46 | 4.27 | 0 | 0.29 | 0 | 0.31 |
| F202L (rs138281308) | 0.54 | 0 | 0.27 | 0 | 0.28 | 1.06 | 1.09 | 0 | 0 | 0 | 0 |
| I251L (rs52820871) | 0 | 0.27 | 0 | 0 | 0.26 | 0 | 0 | 0.90 | 0.43 | 0 | 0.10 |
| Total | 9.89 | 1.07 | 1.60 | 0 | 3.52 | 7.80 | 7.74 | 1.59 | 1.59 | 1.79 | 2.86 |
a
1000 Genomes frequency data determined via ENSEMBL Variant Effect Predictor (VEP).
b
Includes only populations residing on the African continent, namely the Esan from Nigeria; Gambian in Western Division, The Gambia; Luhya in Webuye, Kenya; Menda in Sierra Leone; Yoruba in Ibadan, Nigeria.