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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2015 Jun 16;87:15–25. doi: 10.1016/j.freeradbiomed.2015.05.045

Fig. 3.

Fig. 3

Metformin attenuates the TBI-induced HSC reduction. The mice were sham-irradiated as a control or irradiated and then treated with vehicle or metformin as described in the text. The frequency of HSCs in Lin− BMCs was analyzed by flow cytometry after the mice were euthanized 4 weeks after exposure to TBI. (A) Representative results of the HSC flow cytometric analysis. (B) The frequencies of HSCs in Lin− BMCs are presented as the means ± SE of three independent experiments. ap < 0.05 vs control; bp < 0.05 vs vehicle + TBI.