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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Cancer. 2015 Oct 6;122(1):50–60. doi: 10.1002/cncr.29674

Table 4c. Relative adjusted hazard ratio of multiple chemotherapy agents versus single chemotherapy agent across years of diagnosis.

Period (years) HR *(95% CI) P-value Ratio a (95% CI) P-value Ratio b (95% CI) P-value
1991-1995 (N=2123) 0.883(0.776- 1.005) 0.060 1 (Ref) - - -
1996-2000 (N=3083) 0.855 (0.759- 0.964) 0.010 0.968 (0.886 - 1.057) 0.472 1 (Ref) -
2001-2005 (N=6537) 0.832 (0.769 - 0.901) <.001 0.942 (0.88 - 1.009)) 0.087 0.973 (0.911 - 1.04) 0.426
*

HR (Hazard Ratio) is calculated by the multivariable Cox proportional hazards model with the multiple chemotherapy agents (compared to a single chemotherapy agent) after adjusting for age, sex, race, stage, Medicare status, urban/rural, and radiation. HR decreases over time (p-value < .001).

a

Ratio is the ratio of the adjusted HR for multiple chemotherapy agents (compared to single chemotherapy agent) for the diagnosis year of 1996-2000or 2001-2005 relative to the adjusted HR for multiple chemotherapy agents (compared to single chemotherapy agent) for the diagnosis year of 1991-1995.

b

Ratio is the ratio of the adjusted HR for multiple chemotherapy agents (compared to single chemotherapy agent) for the diagnosis year of 2001-2005 relative to the adjusted HR for multiple chemotherapy agents (compared to single chemotherapy agent) for the diagnosis year of 1996-2000.