Table 2.
Top astrocyte-enriched genes shared by humans and mice, and those only present in human or mouse astrocytes. Shared astrocyte genes are expressed in both human and mouse astrocytes (FPKM > 0.5) and enriched by at least 4 fold over the average expression in neurons, oligodendrocytes, microglia/macrophages, and endothelial cells. Species-specific astrocyte genes have FPKM values < 1 in astrocytes from the non-enriched species, and those that are also astrocyte enriched are indicated with asterisks. Top 20 genes are listed for all categories (ranked by fold enrichment).
| Human and Mouse Astrocyte Specific Markers | Genes in human astrocytes not found in mouse astrocytes | Genes in mouse astrocytes not found in human astrocytes | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene symbol |
Human expression |
Mouse expression |
Gene symbol |
Human astrocyte expression |
Mouse astrocyte expression |
Fold enrichment in human astrocytes / mouse astrocytes |
Gene symbol | Human astrocyte expression |
Mouse astrocyte expression |
Fold enrichment in mouse astrocytes / human astrocytes |
| GJA1 | 560.3 | 351.5 | WIF1* | 66.9 | 0.1 | 668.7 | PLA2G7* | 0.2 | 138.0 | 866.5 |
| SLC39A12 | 79.3 | 88.6 | PMP2 | 80.1 | 0.1 | 663.8 | H3F3A | 0.1 | 56.2 | 561.9 |
| GJB6 | 106.0 | 88.8 | GSTM2* | 43.6 | 0.1 | 331.1 | THRSP | 0.1 | 36.1 | 360.6 |
| BMPR1B | 27.0 | 24.7 | LRRC3B* | 29.7 | 0.1 | 245.0 | ITIH3* | 0.1 | 28.5 | 285.2 |
| SLC14A1 | 29.3 | 37.8 | HSD17B6* | 20.5 | 0.1 | 204.6 | LXN* | 0.2 | 61.2 | 265.0 |
| PAMR1 | 23.1 | 23.8 | FAM198B* | 20.0 | 0.1 | 198.9 | VCAM1* | 0.2 | 45.6 | 226.6 |
| RGS20 | 17.9 | 52.6 | PNMA1 | 26.1 | 0.1 | 187.7 | NNAT | 0.1 | 21.8 | 218.3 |
| FGFR3 | 38.4 | 182.4 | MRVI1* | 18.3 | 0.1 | 183.2 | TNFRSF19 | 0.2 | 37.9 | 217.6 |
| MGST1 | 72.4 | 18.1 | RYR3* | 16.0 | 0.1 | 160.0 | NGEF | 0.1 | 22.1 | 211.9 |
| SLC4A4 | 97.6 | 199.4 | GSTM3 | 19.3 | 0.1 | 144.1 | SNAPC5 | 0.1 | 19.6 | 195.7 |
| AQP4 | 450.0 | 198.4 | APOC2 | 15.3 | 0.1 | 137.4 | CHST2 | 0.3 | 57.3 | 195.0 |
| F3 | 126.1 | 112.6 | RGN | 18.1 | 0.1 | 133.5 | MAGOH | 0.1 | 18.0 | 180.0 |
| MLC1 | 15.3 | 242.3 | ACBD7* | 21.6 | 0.2 | 132.3 | ROMO1 | 0.1 | 16.9 | 169.3 |
| ELOVL2 | 41.2 | 34.2 | RGR* | 12.5 | 0.1 | 115.6 | AKR1B10 | 0.1 | 16.2 | 161.9 |
| SLC1A2 | 1987.9 | 1087.4 | AMY2B | 11.5 | 0.1 | 114.5 | FAM176A | 0.1 | 16.4 | 160.5 |
| CLU | 384.2 | 769.3 | NDUSF5 | 27.3 | 0.2 | 112.3 | IL18* | 0.7 | 107.8 | 154.8 |
| ACSBG1 | 19.6 | 140.8 | STOX1* | 18.1 | 0.2 | 107.3 | POU3F3 | 0.1 | 15.1 | 150.6 |
| TTYH1 | 16.4 | 360.5 | GPR98* | 50.3 | 0.5 | 97.1 | FAM173A | 0.1 | 16.2 | 145.9 |
| ATP1B2 | 468.7 | 550.7 | AADAT* | 10.7 | 0.1 | 79.2 | RNF5 | 0.2 | 24.6 | 142.9 |
| SOX9 | 50.5 | 57.7 | CALCOCO2 | 10.5 | 0.1 | 75.4 | TSPAN2 | 0.1 | 13.5 | 134.4 |
*
Denotes a gene that is also enriched >4 fold in astrocytes over other CNS cell types