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PF-06463922 displays on-target activity in NB and NSCLC cells. A. NB-1643, B. SH-SY5Y, and C. NCI-H3122 cells were treated with increasing concentrations of crizotinib or PF-06463922. Levels of ALK autophosphorylation at Y1278 in the kinase activation loop were analyzed by Western blotting 24 hours after treatment as described in Methods.
