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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mol Cancer Ther. 2015 Nov 19;15(1):48–59. doi: 10.1158/1535-7163.MCT-15-0527

Figure 1.

Figure 1

Polyploidy is a feature of many cancers. A. Chromosome number in multiple cancer types from Mitelman database. RCC = renal cell carcinoma; DLBCL = diffuse large B-cell lymphoma. B. (top) Representative 3-color centromeric FISH images from breast cancer tissue microarray analysis of 354 distinct breast cancers. A total of 6 chromosomes were sampled by centromeric probes (4, 10, 17 on one section and 3, 7, 9 on a separate section). (bottom) Mean ploidy status by 6-chromosome sampling of 354 breast cancers by subtype. C-F. Kaplan-Meier survival curves for polyploid versus non-polyploid cancers. C. Recurrence-free survival for tissue microarray (TMA) cohort where polyploid tumors are defined as those that have mean ≥3 centromere signals per cell among 6 centrosomes counted. D. Overall survival for TMA cohort. E. Relapse-free survival in single-chromosome FISH cohort where polyploid tumors are those defined as those that have mean ≥3 centromere 17 per cell. F. Overall survival for single-chromosome FISH cohort.