Table 2.
Parameter estimates from the single time assessments Eq. (1) for the individual drugs in two cell lines
| Cell line | MiaPaCa-2 | BxPC-3 | |
|---|---|---|---|
|
| |||
| Parameter (units) | Definition | Estimate (CV %) | Estimate (CV %) |
| R0Gem(cells × 103/mL) | Cell number in the absence of gemcitabine on day 3 | 809 (3.59) | 339 (2.89) |
| Imax,Gem | Maximum inhibition effect of gemcitabine | 0.637 (3.01) | 0.810 (1.51) |
| IC50,Gem(nM) | Gemcitabine concentration at half-maximal effect | 22.7 (11.9) | 16.8 (7.16) |
| γGem | Hill coefficient for gemcitabine | 1.38 (11.0) | 1.79 (9.03) |
| R0Et743(cells × 103/mL) | Cell number in the absence of Et-743 on day 3 | 324 (7.46) | 145 (6.10) |
| Imax,Et743 | Maximum inhibition effect of Et-743 | 0.965 (0.433) | 0.964 (0.731) |
| IC50,Et743(nM) | Et-743 concentration at half-maximal effect | 0.851 (7.04) | 0.599 (17.7) |
| γEt743 | Hill coefficient for Et-743 | 4.46 (15.4) | 0.921 (8.42) |