Table 3.
Pharmacodynamic model parameter estimates for time-course studies Eq. (3) and (4) for the two cell lines.
| Cell line | MiaPaCa-2 | BxPC-3 | |
|---|---|---|---|
|
| |||
| Parameter (units) | Definition | Estimate (CV %) | Estimate (CV %) |
| kg(hour−1) | Growth rate constant | 0.0475 (1.44) | 0.0451 (2.17) |
| R0(cells × 103/mL) | Cell number on day zero when drug was added | 38.4 (1.00) | 16.0 (1.62) |
| Kmax,Gem(hour−1) | Maximal cell kill constant for gemcitabine | 0.166 (15.6) | 0.0613 (5.53) |
| KC50,Gem(nM) | Gemcitabine concentration inducing 50 % of | 41.5 (3.61) | 21.4 (6.59) |
| γGem | Hill coefficient for gemcitabine | 3.82 (6.70) | 2.07 (7.72) |
| 1/τGem(hour−1) | Transit constant for gemcitabine | 0.0343 (8.47) | 0.0671 (5.92) |
| Kmax,Et743(hour−1) | Maximal cell kill constant for Et-743 | 0.0858 (2.50) | 0.261 (17.0) |
| KC50,Et743(nM) | Et-743 concentration inducing 50 % of | 1.63 (1.39) | 6.31 (10.6) |
| γEt743 | Hill coefficient for Et-743 | 3.60 (5.06) | 1.07 (7.38) |
| 1/τEt743(hour−1) | Transit constant for Et-743 | 0.0932 (3.86) | 0.0452 (9.44) |
| ψ | Interaction parameter | 0.806 (3.96) | 0.843 (8.64) |
| RSS(cells × 103/mL) | Cell number at steady-state | 1296 (3.95) | 433.6 (6.35) |