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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Trends Immunol. 2015 Dec 11;37(1):17–31. doi: 10.1016/j.it.2015.11.007

Figure 2.

Figure 2

The structure and transcriptional activation of Ahr. (A) Functional domains of Ahr. bHLH (basic helix – loop – helix); PAS (Per – Arnt – Sim) domain containing PAS A and B repeats; Q-rich (glutamine rich) region; the location of functional domains are indicated by double arrows. (B) Transcriptional activation of Ahr. Ligands diffuse into the cell and are bound by the cytosolic Ahr complex. The ligand-bound receptor complex translocates into the nucleus and heterodimerizes with ARNT. Ahr-ARNT complex binds to AhRE, leading to transcriptional activation of target genes.