Table 1. Study design.
| Cohort | CRL rat number | HAR rat number | Duration | Procedures (Number of animals) |
|---|---|---|---|---|
| 1 | 6 | 12 | 25 weeks | • Weekly weights (all animals) |
| • Blood sampling (CRL: n=4), (HAR: n=5) | ||||
| • Organ weights (CRL: n=5) HAR: n=12) | ||||
| 2 | 8 | 5 | 25 weeks | • Weekly weights (all animals) |
| • Weekly food consumption measurement (all animals)-week 13 to 24 | ||||
| • Blood sampling (CRL: n=4, HAR: n=4) | ||||
| • QMR body composition analysis (CRL: n=5, HAR: n=5) | ||||
| • Organ weights (CRL: n=8, HAR: n=5) | ||||
| • Epididimal fat (CRL; n=8, HAR: n=5) | ||||
| • Tibia length measurement (CRL: n=8, HAR: n=5) |