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. 2015 Jul 28;7(1):28–45. doi: 10.1007/s13238-015-0193-x

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Scheme of influenza C virus and influenza A/B virus particles. Proteins having the same function are depicted with the same symbol. Note that influenza C virus has only one spike protein, the hemagglutinin-esterase-fusion glycoprotein HEF that combines the functions of both hemagglutinin (HA) and neuraminidase (NA) from influenza A and B virus. PB1, PB2, P3 and PB1, PB2, PA are the polymerase proteins of influenza C virus and influenza A/B virus, respectively, that build together with the nucleoprotein NP and the viral RNA-segments the ribonucleoprotein complexes (vRNP). M1 is the matrix protein and M2 and CM2 the proton-channel