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. 2015 Jul 28;7(1):28–45. doi: 10.1007/s13238-015-0193-x

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Structure of the seven influenza C virus genome segments. Open reading frames (ORFs) are indicated in black. Segment six and seven encode two proteins which are generated by splicing. Influenza C virus possesses 7 minus-senses, single-strand and segmented RNA. Each segment possesses 12 conserved nucleotides at 3′ terminal and 11 conserved nucleotides at 5′ terminal. A poly U motif is close to 5′ terminal and it transcripts into mRNA poly A tail. Each of the longest 5 segments possesses only 1 open-reading-frame (ORF) and encodes PB2, PB1, P3, HEF and NP, respectively