Figure 1.

Summary of kinases known to regulate tonicity-dependent activation/inactivation of NFAT5 through an increase/decrease of its transactivating activity, nuclear localization and/or protein abundance. If none of these three steps appears with an arrow, this means that the mechanism is unknown. mTOR: Mammalian target of rapamycin; TA: Transactivating activity; NL: Nuclear localization; PA: Protein abundance; PKA: Protein kinase A; PKC: Protein kinase C; ERK: Extracellular signal-regulated kinase; CDK: Cyclin dependent kinase.