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. 2015 Jul 2;147(2):425–435. doi: 10.1093/toxsci/kfv138

FIG. 5.

FIG. 5.

AHR regulates NKX2-5 expression in the developing heart. A, Higher digital magnification of 5-µm sections of embryonic left atrium collected at E15.5 from Ahr−/− and Ahr+/+ either naïve or exposed to TCDD in utero, used for immunohistochemical detection of NKX2-5 (DAB-positive nucleus shown by red arrow in inset; negative nucleus shown by green arrow). Harris hematoxylin counterstained. B, Quantification of NKX2-5-positive nuclei relative to total nuclei at the indicated embryonic developmental times. The NKX2-5 index is shown as the mean percent NKX2-5-positive nuclei ± SEM; *P ≤ .05. Full color version available online.