Table 3.
Hepatocellular carcinoma.
| Reference | Radiation | Dose GyE | Dose/Fx GyE | Stage | Size (Ave) | n | Local control (%) | Late toxicity ≥grade 3 |
|---|---|---|---|---|---|---|---|---|
| Andolino et al. (31) | X | 36–48 | 13–16 | CPC-A | 3.2 cm | 36 | 90 at 2 years | 35% heme/liver |
| 40 | 8 | CPC-B | 24 | |||||
| Bujold et al. (32) | X | 24–54 | 4–9 | CPC-A | 7.2 cm | 102 | 87 at 1 year | 30% (7 G5) |
| Culleton et al. (33) | X | 30 | 5 | CPC-B | 5.1 cm | 28 | 55 at 1 year | 63% ↑CP ≥2 |
| CPC-C | 1 | |||||||
| Fukumitsu et al. (82) | P | 66 | 6.6 | CPC-A | 2.8 cm | 51 | 88 at 5 years | 1 Lung |
| CPC-B | ||||||||
| Chiba et al. (83) | P | 72 | 4.5 | CPC-A–C | 3.8 cm | 162 | 87 at 5 years | 3% ≥G2 |
| Bush et al. (84) | P | 63 | 4.2 | CPC-A–C | 5.5 cm | 76 | 80 (2–60 m) | None |
| Komatsu et al. (85) | P | 52.8–84 | 2–13.2 | CPC-A–C | <5 cm 74% | 242 | 90 at 5 years | 3% |
| C | 52.8–76 | 3.8–13.2 | 101 | 93 at 5 years | 4% | |||
| Kato et al. (86) | C | 49.5–79.5 | 3.3–5.3 | CPC-A–B | 5 cm | 24 | 81 at 5 years | 25% ↑CP ≥2 |
X, photon therapy; P, proton therapy; C, carbon-ion therapy; Fx, fraction; GyE, gray or gray equivalent; n, patient number; CPC, Child–Pugh Class.