Table 4.
Frequencies and association of Tumor Necrosis Factor Alpha (− 308G/A, + 488G/A, − 857C/T and -1031 T/C) haplotypes in IS patients and controls.
| Haplotypes | IS cases n (%) |
Controls n (%) |
Odds Ratio (95% CI) | P value |
|---|---|---|---|---|
| G308-G488-C857-T1031 | 248 (49.6) | 253 (50.6) | Reference | |
| G308-G488-C857-C1031 | 87 (17.2) | 112 (22.4) | 0.56 (0.56–1.10) | 0.16 |
| G308-G488-T857-T1031 | 31 (6.2) | 26 (5.2) | 1.21 (0.70–2.10) | 0.69 |
| G308-G488-T857-C1031 | 31 (6.2) | 26 (5.2) | 1.21 (0.70–2.10) | 0.69 |
| G308-A488-C857-T1031 | 13 (2.6) | 23 (4.6) | 0.57 (0.28–1.16) | 0.12 |
| G308-A488-C857-C1031 | 6 (1.2) | 3 (0.6) | 2.04 (0.50–8.24) | 0.31 |
| G308-A488-T857-T1031 | 49 (9.8) | 30 (6) | 1.66 (1.02–2.71) | 0.03 |
| A308-G488-C857-T1031 | 35 (7) | 27 (5.4) | 1.32 (0.77–2.25) | 0.30 |
| Total | 500 | 500 | ||