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. 2016 Jan 11;9:506. doi: 10.3389/fncel.2015.00506

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Copyright © 2016 Fuller, Mandefro, Shirran, Gross, Kaus, Botting, Morris and Sareen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perturbation of developmental and differentiation pathways in SMA motor neurons. (A) A Venn diagram and bar chart illustrates the number of differentially expressed proteins seen in control motor neurons (n = 1) compared to control fibroblasts (n = 1) (blue circle and blue bars) and SMN motor neurons (n = 1) compared SMA fibroblasts (n = 1) (green circle and green bars). (B) Bioinformatics analysis of the 46 proteins that were only increased in the control motor neurons vs. control fibs was conducted using the Database for Annotation, Visualization and Integrated Discovery (DAVID). CTR, control; MNs, motor neurons.