Table 1.

Differentially-expressed proteins with opposite expression levels in SMA fibroblasts compared to SMA motor neurons from the same patient.

Protein name	Accession number	Sequence coverage (%)	Avg. iTRAQ ratio (SMA fibs/CTR fibs)	Avg. iTRAQ ratio (SMA MNs/CTR iMNs)
Myosin-3	P11055	52.5 [122]	0.75	5.95
Caldesmon	Q05682	42.0 [23]	0.71	1.92
Zyxin	Q15942	27.1 [18]	0.72	1.47
Synaptopodin-2	Q9UMS6	10.0 [3]	0.66	1.38
UCHL1	P09936	56.1 [37]	1.40	0.68
CNP	P09543	30.6 [3]	1.41	0.54

Differentially-expressed proteins that were changed in one direction (i.e., up- or down-regulated) when SMA fibroblasts were compared to control fibroblasts, but changed in the opposite direction when SMA motor neurons were compared to control motor neurons. Only statistically significant differential expression (i.e., those with p < 0.05) are shown. Abbreviations in column headings refer to the following: protein name, given name in Swiss-Prot database; [n], number of unique peptides used for quantification; fibs, fibroblasts; SMA MNs, 32i motor neurons; CTR MNs, 14i control motor neurons.