Figure 3.

Functional links predicted by String 10 among candidates for the evolution of language (nodes in gray) and the horizontally-transferred genes from viruses highlighted here as potential new candidates (nodes in green). Stronger associations between proteins are represented by thicker lines. The medium confidence value was 0.0400 [a 40% probability that a predicted link exists between two enzymes in the same metabolic map in the KEGG database (http://www.genome.jp/kegg/pathway.html)]. String 10 predicts associations between proteins that derive from a limited set of databases: genomic context, high-throughput experiments, conserved coexpression, and the knowledge previously gained from text mining (Szklarczyk et al., 2015). This is why the figure does not represent a fully connected graph (evidence for additional links are provided in the main text). Importantly, the diagram only represents the potential connectivity between the involved proteins, which has to be mapped onto particular biochemical networks, signaling pathways, cellular properties, aspects of neuronal function, or cell-types of interest that can be confidently related to aspects of language development and function (see Table 1).