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. 2016 Jan 11;6:644. doi: 10.3389/fimmu.2015.00644

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Copyright © 2016 Heather, Best, Oakes, Gray, Roe, Thomas, Friedman, Noursadeghi and Chain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The repertoires of HIV-infected individuals have a smaller number of distinct sequences, and lower diversity. (A) The total number of alpha (left) and beta chain (right) CDR3 sequences obtained from each HIV⁻ and HIV⁺ individual, at both the pretreatment (S1) and treated (S2) bleed. The bars show mean and SD. (B) As for (A) but showing the number of unique CDR3 sequences observed within each set. The difference between the mean of the HIV⁻ and HIV⁺ S1 samples was significant, p < 0.01. There was no significant difference between HIV⁺ S1 and HIV⁺ S2. (C) As for (A) but showing CDR3 diversity measured by the Shannon information index (or Shannon entropy) for each sample.