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. 2016 Jan 11;6:644. doi: 10.3389/fimmu.2015.00644

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Copyright © 2016 Heather, Best, Oakes, Gray, Roe, Thomas, Friedman, Noursadeghi and Chain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered distribution and interindividual differences in V gene usage in the repertoires of HIV⁺ individuals. The frequency of V alpha (A) and V beta (B) gene usage for the unique TCR repertoires of each donor sample within the two groups (HIV⁻ in black or untreated HIV⁺ in red). Bars show the mean proportion for each V gene in each group. Asterisks (*) show those V genes, which differ significantly in their usage (T test, p < 0.05) between HIV⁻ and HIV⁺. Interindividual differences in patterns of V gene usage (measured using Jensen–Shannon distances) for alpha (C) and beta (D) V genes. The plot shows the median and interquartile range of the Jensen–Shannon distances between each individual and all other individuals in turn from the same group. HIV⁻ are shown in black; HIV⁺ are shown in red.