Figure 1.

Effect of insulin treatment on glycemic levels and mechanical sensitivity. (a) Insulin injection decreases blood glucose levels at 30 and 60 min after insulin injection. (b) Mechanical sensitivity is increased (shown as decreased withdrawal thresholds) at 40, 90, and 150 min after insulin treatment. (c) Normal saline as control of insulin does not significantly affect blood glucose level or mechanical sensitivity (d). ∗ and ∗∗∗ represent p < 0.05 and p < 0.001, respectively, with ANOVA test.